The incident happened just after 7:00 p.m. at the 7-Eleven located at 150 East Champlost Avenue.
Two armed suspects wearing masks entered the convenience store, police say.
One suspect approached the counter and pointed a gun at an employee and demanded money.
The second suspect also pointed a gun at another employee to force them to help in emptying the cash register.
Both suspects fled the store after getting an unknown amount of cash.
They were last seen on foot going west on Champlost Avenue.
The first suspect is described as a black male, dark complexion, late teen to early 20's, 5'8" tall and thin build.
He was wearing a gray sweatshirt, dark colored cargo style pants, dark colored sneakers, blue knit hat covering his face and armed with a handgun possibly a revolver.
The second suspect is described as a black male, early to mid-20's, goatee, 6"0" tall and medium build.
He was wearing a navy blue jacket, black pants, dark colored sneakers and armed with a black semi-automatic handgun.
Anyone with information is urged to contact Philadelphia Police at 215-686-TIPS (8477), text a tip to PPD TIP (773847) or through PhillyPolice.com.