Spears' show debuts Dec. 27, just in time for Sin City's massive New Year's crowds. The 32-year-old will perform 50 shows each in 2014 and 2015, performing her top hits and more recent material.
The show will take place in a relatively small theater with nightclub touches, including table and bottle service.
Spears has released seven platinum-plus albums since she debuted on the music scene in 1999. She has more than a dozen Top 10 hits, including "Toxic," ''Gimme More" and "Oops! ... I Did It Again."
Her eighth album, "Britney Jean," was released this week to tepid reviews.
David Hoenemeyer, president of Planet Hollywood, said the pop star has a bigger following than any other musician playing on the Strip.
"She really cuts across all demographics. She has a remarkable following, and the ticket sales reflect that," he said. "It's a really big deal to have a star of her caliber performing for us."