Police responded at approximately 6:07 p.m. to reports of gunfire at a home in the 2600 block of North Van Buren Street.
Inside, they found 17-year-old Lamar Wilmer of Wilmington. He had been shot several times.
Police administered first aid and CPR.
Medics rushed the victim by ambulance to Christiana Hospital, where he was pronounced dead.
There was no immediate word on suspects or a motive.
Police said this is the city's 20th homicide investigation of 2013.
The Associated Press contributed to this report.