The accident occurred around 10:30 p.m. near the Betsy Ross Bridge on Route 130 and Union Avenue.
According to police, two vehicles collided head on.
One car carrying a male and female were allegedly driving at a high rate of speed and traveling north on Route 130 when it struck a second car.
The striking car lost control and continued north, flipping over a guard rail before ejecting the male and female victims.
Both victims were taken to the hospital in critical condition.
The driver in the second car suffered minor injuries and was taken to the hospital for treatment.
Police are investigating the crash.