It happened on December 7th at 2:05 a.m. at Smith Pharmacy in the 800 block of East Hunting Park Avenue in Hunting Park.
Surveillance video recorded from several angles shows the men breaking in to the business through the front door, then going aisle to aisle stealing bottles of narcotics.
They fled on foot in an unknown direction.
Detectives are looking for two white or Hispanic men. Both were wearing dark colored hooded sweatshirts, dark pants and dark shoes. One man's pants had a white stripe running down the side.
Anyone with information is urged to contact Philadelphia Police at 215-686-TIPS (8477), text a tip to PPD TIP (773847) or through PhillyPolice.com.