The crash happened around 12:15 a.m. in the 100 block of East Sharpnack Street.
Police say the driver of that minivan collided with another vehicle, sending that vehicle into a parked car.
A 75-year-old man and a 45-year-old man, both said to be passengers, were taken to the hospital in stable condition.
There was no immediate word on the identity of the driver.
An investigation into the circumstances of this crash continues.