It happened around 2:00 a.m. Saturday at the Hampton Inn on the 8600 block of Bartram Avenue.
Authorities say a woman left two suitcases at the hotel and walked away. When someone told her about the suitcases, the woman reportedly said she didn't want them.
The woman then got into a shuttle and asked to be dropped off at any terminal at the Philadelphia Airport.
Police were able to determine that the suitcases belonged to a homeless woman. They were able to locate her, and she was transported to a homeless shelter.
The hotel relocated over 100 people during the investigation.
No evidence of explosives or other suspicious items were found.
Police cleared the scene and the suitcase around 3:45 p.m. and the guests were allowed to return to the hotel.
The incident remains under investigation.