Firefighters were called to 12006 Salina Place just after 9:00 a.m.
Crews arrived to find heavy smoke and fire coming from the second floor row home.
"They frantically started their search, knocked down the fire, opening up some of the heat out of the building," said Fire Commissioner Lloyd Ayers.
When they entered the house, authorities say there were so many items inside, they believe the father and son might have been hoarders.
"There's debris everywhere, everywhere," said Commissioner Ayers.
Crews discovered the two men in the living and dining room areas and say it appears that they tried to get out.
"We saw a fire that could've been prevented and if we had the hoarding situation out of the pathway people could have gotten out," said Commissioner Ayers.
Crews describe rooms full of up to four or five feet with food, cassette tapes and other items.
Neighbor Fran Posadowski never went inside but knew both victims for 25 years.
"I loved them to death the both of them," said Posadowski.
Every week she made them a big bowl of pasta and she spoke to them just yesterday.
"He called me last night and I said, 'I'm going to make you pasta and I'll bring it over to you tomorrow,' and he brought me sugar free candy," said Posadowski.
Officials say there was at least one working smoke detector in the home. The cause for the fire remains under investigation.