The shooting occurred just before 11:30 p.m. on the 800 block of East Price Street.
According to police, a man in his 20's was found in the dining room with a gunshot wound to the head.
He was pronounced dead at the scene.
Police say, someone burst through a glass window on the second floor to escape.
It's unclear if that person was the gunman, or an innocent bystander who was in danger.
So far, there is no word on suspects or a motive.
Homicide detectives are investigating.