It happened after 7:00 a.m. Friday at Newport-Gap Pike and Meadowbrook Avenue in Belvedere.
Police tell Action News the bus collided with a Cadillac SUV. Two people in the Cadillac suffered non-life-threatening injuries, and one student on the bus suffered minor injuries.
The bus was enroute to DelCastle High School.
There was no immediate word on how many students were onboard at the time of the crash.
An investigation is underway.