The accident happened just before 9:00 a.m. Wednesday on Route 82 between Route 30 and Route 340.
At least seven vehicles were involved in the incident.
The roadway was shut down for close to an hour while crews worked to clear the scene.
Meanwhile in Upper Macungie Township, Lehigh County, police are investigating a crash between a car and a delivery truck.
It happened around 9:15 Wednesday morning on Route 100 and Nursery Street.
The exact details of the accident are unclear.
No one was injured in either crash.