The crash happened just before 5:30 a.m. Thursday. It was one of many blamed on icy conditions in the area.
The accident involved four vehicles: a box truck, a Pennsylvania State Police patrol car and two passenger sedans. At least one person became trapped in the wreckage.
Images from Chopper 6 HD over the scene showed the box truck lying on its side on top of one of the sedans. Another passenger vehicle was nearby with extensive damage. A Pennsylvania State Police patrol car also appeared to have sustained some rear-end damage.
Multiple rescue units were on the scene. One person was seen being taken from one of the vehicles on a stretcher.
Pennsylvania State Police say a state trooper was taken to the hospital with a leg injury and a minor cut to the head. The driver of the box truck was treated and released from an area hospital.
The driver of one sedan, said to be a Mercedes-Benz, was also taken to an area hospital for evaluation then released.
The early morning crash prompted police to shut down all northbound lanes at the accident scene approaching Route 3 for more than three hours.
The accident was remains under investigation. State police said preliminary indications are ice on the roadway contributed to the crash.
Over in Camden, one driver was injured in a spin out crash just before 5:00 a.m.
An SUV had toppled to its side on the 1400 block of Admiral Wilson Boulevard; the driver was taken to the hospital with various injuries.
In Upper Darby Township, another driver landed in the hospital after a one vehicle crash on State Road near Route 1.
Police say the driver lost control and spun out into a stop sign.
Authorities say ice played a factor in these crashes, as well.
As it got later and the sun got brighter, some of the ice thawed, but many slippery spots remained.