The fire broke out at 3:30 a.m. Wednesday in a one-story home in the 3000 block of North Blue Bell Road.
Police say the couple who lives there was awoken by their barking dog.
Fire officials say the blaze completely destroyed the home. Both residents were able to escape without injury but the flames claimed the lives of the couple's two cats.
The Red Cross is assisting the displaced residents.
Investigators are working to determine what sparked the blaze.