The crash happened just before 6 a.m. at the intersection of Route 41 and Highland Road in Atglen.
Police say it started as a two-vehicle crash involving Ford Explorer and a Toyota Tacoma.
The driver of a tractor-trailer tried to avoid the accident scene, lost control and overturned.
The tractor-trailer driver suffered a cut to his head.
The road was reopened around 8:00 a.m.