It was around 12:45 p.m. when crews were called to the 500 block of South Broad Street.
When firefighters arrived they found heavy fire in the upper floors and roof of the home and struck a second alarm.
There were several residents home when the fire broke out, but everyone was able to get out safely.
Officials say that a neighbors helped some of the residents escape the burning home.
It is unclear at this time what sparked the fire.