The accident happened around 3:45 p.m. on Bartram Avenue near 90th Street.
The driver of the truck was taken to the Hospital of the University of Pennsylvania in an unknown condition.
It is not yet known how the accident happened.
The view from Chopper 6 showed the yellow Penske truck on its side, facing the wrong way, as workers moved cargo out of the truck.
One lane of traffic was still able to get by but all lanes have since reopened.