The fire broke out shortly after 1:00 a.m. on the 4400 block of Teesdale Street.
Firefighters arrived to find flames shooting from the second floor of a vacant house.
They quickly doused the flames and got the fire under control within a half hour.
Two neighboring homes were damaged from the smoke and water.
Eleven people had to leave their homes to stay with family and friends.
There is no word on what sparked the blaze.