It happened in the 1900 block of Market Street after 10:00 a.m. Friday.
Police say a Toyota Corolla was struck by a DART bus and overturned onto a sidewalk.
The 54-year-old driver was taken to Christiana Hospital.
There was no immediate word on the extent of his injuries.
Police said no one on the bus was injured.
Market Street was closed between 18th Street and Concord Avenue for about an hour after the crash.
An investigation into the accident is underway.