The blaze broke out around 9:30 a.m. in a row house located on the 2400 block of York and Cedar Streets.
Neighbors say flames were roaring out of the front of the house and they banged on doors to alert everyone.
Relatives of the victims identified the couple as 73-year-old Sarah Jean Hurst and her 70-year-old husband, Frank Hurst.
Witnesses say the couple's daughter, Allison Hurt arrived to drop off medicine and found the first floor living room engulfed in flames.
She and her husband tried to get her mother and father out of the house.
But they had difficulty because the mother is disabled.
An unidentified passerby heard the daughter's screams for help and came to assist.
The couple was taken to Temple University Hospital for treatment.
They both suffered from burns on their hands and from smoke inhalation.
Firefighters knocked down the flames but not before the 3-story house suffered heavy damage.
There is no word on what sparked the blaze.