It happened after 5:30 a.m. Wednesday in a construction zone in the southbound lanes approaching the Girard Avenue exit.
The crash blocked the right lane of the highway for 15-20 minutes.
Images from a Sky 6 traffic camera showed 5 or 6 cars stopped in the right shoulder. Police were on the scene.
There was no immediate word on injuries or what led to the crash.
The accident led to a major backup on southbound I-95 from Girard Avenue to the Bridge Street exit during the morning rush hour.