"Rene Angelil, 73, passed away this morning at his home in Las Vegas after a long and courageous battle against cancer. The family requests that their privacy be respected at the moment; more details will be provided at a later time," a message reads on CelineDion.com.
Angelil, who has been married to the famed singer since 1994, had been battling cancer for some time.
Angelil had been Dion's longtime manager for more than 30 years, but stepped down in 2014 after his throat cancer had returned. He was recovering from an operation to remove a tumor in his throat.
He first battled cancer in late 1990's.
Also in 2014, Dion, 47, took some time off from her regular residency in Las Vegas to be with her husband. When she returned to the stage last year, she spoke to ABC News about life at home taking care of the father of her children. Dion and Angelil have three sons together.
"We are afraid of explaining [the cancer to the kids] because we're scared, because we're worried ... We are taking life one day at a time," she said. "Like I said to my children, 'You want to come and help me feed papa today...You want to help me out? Want to hold the water? You are a good feeder. Good job, Nelson. Good job, Eddie. Thank you so much. Come on, give a kiss to papa.'"
Dion also opened up about when she found out her husband's cancer was back after almost 15 years.
She was just about to go on stage, but "I went back in my dressing room and I saw him looking pretty devastated, in shock, and I was like, 'What's going on?' He said, 'I have cancer again. The doctor just called me and I have cancer again.'"
Angelil is survived by his wife, and their sons -- Rene-Charles, 14, and twins Nelson and Eddy, 5.
IN MEMORIAM: Celebrities and notable figures who have recently passed away