PHILADELPHIA --Eagles starting right guard Brandon Brooks was hospitalized with an illness earlier Monday and is inactive for the game against the Green Bay Packers.
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Rookie Isaac Seumalo will replace Brooks in the starting lineup.
Brooks has been one of the team's more consistent offensive lineman this season. The former Houston Texan signed a five-year, $40 million contract to join the Eagles via free agency this offseason, and the move helped solidify a guard position that gave them plenty of trouble in 2015.
With Brooks out, quarterback Carson Wentz will be operating behind a line that is missing two of its original members, with a third, Barbre, playing out of his intended position.
Philadelphia is also missing two other starters: running back Ryan Mathews and right tackle Halapoulivaati Vaitai. Both players have knee injuries. Wide receiver Nelson Agholor, a 2015 first-round pick, is a healthy scratch.
Darren Sproles and rookie Wendell Smallwood replace Mathews. Allen Barbre shifts from left guard to take Vaitai's spot. Rookie Isaac Seumalo makes his first career start in Brooks' spot.
The Packers are missing linebackers Jake Ryan and Blake Martinez, offensive linemen T.J. Lang and JC Tretter. But cornerback Damarious Randall returns to their lineup.
Cornerback Demetri Goodson, linebacker Kyler Fackrell and defensive tackle Christian Ringo are also inactive for Green Bay (4-6).
Defensive linemen Steven Means and Taylor Hart and guard Dillon Gordon are out for Philadelphia (5-5).
ESPN contributed to this report.