The shooting happened Friday just before 1:30 p.m. on the 2500 block of North Bancroft Street.
Officials say shots rang out that ended up hitting the 50-year-old victim.
The woman, whose identity remains unknown, was rushed to Temple University Hospital where she was pronounced dead a short time later.
Authorities say they believe the shooter was in a newer model burgundy Chevy Impala.
So far, no arrests have been made.