Police said the shooting happened at about 6:20 p.m. in the 3000 block of Bambrey Street.
The man was shot multiples times in the chest and was pronounced dead at the scene, police said.
Lawanna Rawls says her brother was a victim of a robbery gone wrong.
"My brother John Rawls was a good man," she said. "Whoever it was kicked the door in and tried to rob him but my brother don't give nothing up he fought back. I think he fought back."
She said Rawls had lived in the neighborhood for about five years.
Police said a weapon was recovered, but no arrests have been made.
Saturday's homicide marked the city's 25th homicide of 2020.