The fire broke out in the store's café just before 5 a.m. Tuesday on the 200 block of Rowan Boulevard in Glassboro.
Fire crews arrived to find heavy smoke throughout the building.
It took about a half hour to get the fire under control.
No injuries were reported.
Rowan University issued the following statement:
"Barnes & Noble will be closed today, Tuesday, Nov. 8, due to a small fire in its cafe. No one was injured and the fire was put out quickly by fire suppression systems. Smoke filled the store, however. Thank you for your patience."