Biden took the stage shortly after 8 p.m. on Thursday at Independence Historical Park in Philadelphia, where several hundred people were sitting in white lawn chairs and Independence Hall's facade was lit up in red and blue.
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"This is where the United States Constitution was written and debated," Biden said. "This is where we set in motion the most extraordinary experiment of self government the world has ever known."
"But as I stand here tonight, equality and democracy are under assault," he continued. "We do ourselves no favor to pretend otherwise. So, tonight, I've come to this place where it all began, to speak as plainly as I can to the nation about the threats we face, about the power we have in our hands to meet these threats and about the incredible future that lies in front of us if only we choose it."
FULL SPEECH: Biden delivers address outside Independence Hall on 'extremist threat to democracy'
President Biden addresses 'extremist threat to democracy': Full speech
The president mentioned his Oval Office predecessor by name as he assailed Republicans who refuse to accept the 2020 election results, defend those who stormed the Capitol on Jan. 6 or want to strip away abortion rights and other privacy concerns.
"Too much of what's happening in our country today is not normal," he said. "Donald Trump and the MAGA Republicans represent an extremism that threatens the very foundations of our republic."
Biden made a distinction between the so-called MAGA Republicans and other conservatives, stating "not every Republican embraces that extreme ideology."
"I know, because I've been able to work with these mainstream Republicans," he said. "But there's no question that the Republican party today is dominated, driven, and intimidated by Donald Trump and the MAGA Republicans and that is a threat to this country."
Biden's urgent rhetoric mirrors his 2020 messaging, in which he presented himself as a clear contrast to Trump and the race itself as an inflection point for the nation.
He made that comparison again Thursday, telling the crowd: "Now America must choose to move forward or to move backward, to build a future obsessed about the past, to be a nation of hope, unity, and optimism or a nation of fear, division and of darkness."
Administration officials had teased Biden's speech as an extension of his "soul of the nation" message, which first emerged in 2017 after white supremacists clashed with counter protesters in Charlottesville, Virginia -- the incident Biden said inspired him to run for president.
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Biden on Thursday said all Americans are called by "duty and conscience to confront extremists" and to reject political violence.
"We are still at our core a democracy, and yet, history tells us that blind loyalty to a single leader and a willingness to engage in political violence is fatal to democracy," he said.
Biden's appearance in Philadelphia is his second of three stops in the battleground state of Pennsylvania this week alone.
Biden arrives in Philly ahead of speech on 'threat to democracy'
The GOP issued a preemptive rebuttal of Biden's remarks, with House Minority Leader Kevin McCarthy speaking in Scranton (Biden's hometown) just hours before the president took the stage in Philadelphia.
McCarthy criticized Democrats on inflation, crime and the border before demanding Biden "apologize for slandering tens of millions of Americans as fascists" after the president previously described the ideology being adopted by MAGA Republicans as "semi-facism."
"What Joe Biden doesn't understand is that the soul of America is the tens of millions of hard working people, loving families, and law-abiding citizens whom he vilified for simply wanting a stronger, safer, and more prosperous country," McCarthy said.
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"The soul of America is not the ruling class in Washington, it is the law-abiding, tax-paying American citizen," McCarthy said. "The soul of America is our determination to get up and go to work everyday, provide for our families, to love our children, be involved in their education and ensure that this nation and its people always come first."
PENNSYLVANIA IN THE SPOTLIGHT
Biden's trip to Philadelphia was the second of three visits to Pennsylvania in less than a week. He delivered remarks in Wilkes-Barre on Tuesday, and will be in Pittsburgh on Labor Day.
The Keystone State is home to a competitive governor's race and a U.S. Senate contest that could help determine whether Democrats will keep their majority in the chamber.
Democrats believe Pennsylvania is their strongest opportunity to flip a Senate seat currently held by Republicans.
Meanwhile, the open race for governor will give the winner power over how 2024's presidential election is run in a battleground state that is still buffeted by Trump's baseless claims that Democrats fraudulently stole the 2020 election from him.
Former President Donald Trump will campaign for Mehmet Oz and Doug Mastriano at an event in Wilkes-Barre on Saturday.
- ABC News' Justin Gomez, Mary Bruce, Sarah Kolinovsky and Molly Nagle contributed to this report.