It happened around 3:45 a.m. on the 200 block of South 62nd Street.
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Authorities told Action News that a red substance could be seen on the front porch following the explosion.
The bomb squad was called in to investigate.
Investigators said it was determined that an "M-series" device was thrown at the property.
Police said no one was home at the time of the incident and no injuries have been reported.
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The incident remains under investigation with the Southwest Detectives Division.
Anyone with information is asked to contact the police.