It happened Tuesday night around 6:15 p.m. along North Broad Street and Girard Avenue.
Police say they arrived on the scene to find multiple people fighting; one man was suffering from a stab wound to the back.
He was rushed to Temple Hospital for serious injuries but not believed to be life-threatening.
No arrests have been made.
It's unclear what sparked the fight.
Anyone with any information is asked to call police at 215-686-TIPS.