It happened at approximately 6:15 p.m. in the area of Delaware Avenue and Spring Garden Street in the city's Northern Liberties neighborhood.
Officials say a driver with two passengers lost control of the vehicle, causing it to crash into a construction area.
There is no word yet on how the driver lost control.
Officials say a 58-year-old man died as a result of the collision.
There is no word yet on the man's identity.
A 69-year-old male was listed in critical condition at the hospital, and officials did not release the condition of the third passenger.