Cassandra Johnston, 26, of Southampton, was last seen near 12th and Vine streets leaving a home on Saturday around 5:30 a.m.
Her family says she was wearing the same clothing seen in this photo below.
Johnston was driving a silver 2016 Ford Focus with Pennsylvania registration KSA8807.
Anyone with any information is asked to call Lower Southampton police by calling 215-357-1235 ext 339.