Chopper 6 flew over the 4500 block of North 13th Street at about 1:30 p.m. Thursday.
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Investigators told Action News a 15-year-old boy in the home was handling a gun when a shot went off.
The 11-year-old was taken to an area hospital where she was placed in stable condition.
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Action News has learned that the 15-year-old and his mother are in police custody and are expected to face charges in the shooting.