It happened around 12:30 p.m. at the branch along the 2500 block of Welsh Road.
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The thief was caught on surveillance walking up to a bank teller and handing over a demand note.
He got away with an unknown amount of cash before fleeing on foot. No one was hurt during the robbery.
The suspect is described as a black male in his late 30s to early 40s and 5'8"-5'9" tall with a light complexion. He was wearing black-framed eyeglasses, a hunter green winter jacket, black knit cap and black scarf.
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Police say he is considered armed and dangerous.
Anyone with information should call the FBI at 215-418-4000 or the Philadelphia Police Department.
There is a reward for information leading to the suspect's arrest and tipsters can remain anonymous.