The crash happened along City Avenue at Old Lancaster Road around 5:30 a.m. Monday near St. Joseph's University.
Police say it appears the driver lost control, jumped the curb, crossed a parking lot and slammed into the building.
Only the back of the white Nissan Quest could be seen sticking out of the brick wall.
There was no word on whether anyone inside the car or inside the building was injured.
An investigation into the crash continues.