William Adrover Rodriguez, Manuel Castro Velazquez, Jamie Acevedo-Correa, and Elvin Perez-Medina were arrested on March 21, investigators say.
The Mercer County Narcotics Task Force says it acted on a DEA tip that led them to a Motel 6 in Lawrence Township, New Jersey.
Authorities say they discovered 5.1 kilograms of powder cocaine in the motel room, which has a street value of approximately $500,000.
All four suspects now face multiple narcotics charges.