It happened just before 12:30 p.m. Wednesday on Route 141 North, north of the Boxwood Road exit.
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Video from Chopper 6 HD showed three vehicles with significant damage, including two pickup trucks and a white sedan.
Action News is told at least one person was killed. That person's identity has not been released.
No other serious injuries were have been reported.
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Debris from the crash was spread across two lanes.