It happened just before 11 a.m. on the 1900 block of Old Bethlehem Road.
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Both vehicles involved were heavily damaged.
One was up against a house, which also had visible signs of damage.
The other vehicle was on the road but flipped onto its roof.
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At least one person was taken to the hospital.
The view from Chopper 6 showed a person being loaded into a medical helicopter.
There was no immediate word on the cause of this crash.