It happened just before 11 a.m. on the 1900 block of Old Bethlehem Road.
Both vehicles involved were heavily damaged.
One was up against a house, which also had visible signs of damage.
The other vehicle was on the road but flipped onto its roof.
At least one person was taken to the hospital.
The view from Chopper 6 showed a person being loaded into a medical helicopter.
There was no immediate word on the cause of this crash.