Police say a car going east in the westbound lanes on the 2600 block of Roberts Avenue, crossed the center line and slammed into another car head-on.
A passenger in the wrong-way car, a 47-year-old man died.
Police say five others in that car including a six and eight year old all suffered injuries.
The driver of the car that was hit suffered only minor injuries.
The cause of the crash remains under investigation.