A crash involving a tractor trailer shut down a portion of the eastbound expressway in Egg Harbor Township around 7:16 a.m. Saturday.
Authorities said a tractor trailer and Honda Accord crashed into each other.
The impact sent the tractor trailer off the roadway and into woods.
Two people were transported via a medical helicopter to a nearby hospital with serious injuries.
Around 11:30 p.m. Friday, three people were injured after a fiery crash on the expressway.
Police said two cars collided in the westbound lanes near the Cross Keys Road exit in Winslow Township.
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The impact caused one of the vehicles to catch fire.
Firefighters arrived and quickly put out the flames.
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The three victims were taken to a nearby hospital with non-life-threatening injuries.
There is no word on what caused either crash.