A crash involving a tractor trailer shut down a portion of the eastbound expressway in Egg Harbor Township around 7:16 a.m. Saturday.
Authorities said a tractor trailer and Honda Accord crashed into each other.
The impact sent the tractor trailer off the roadway and into woods.
Two people were transported via a medical helicopter to a nearby hospital with serious injuries.
Around 11:30 p.m. Friday, three people were injured after a fiery crash on the expressway.
Police said two cars collided in the westbound lanes near the Cross Keys Road exit in Winslow Township.
The impact caused one of the vehicles to catch fire.
Firefighters arrived and quickly put out the flames.
The three victims were taken to a nearby hospital with non-life-threatening injuries.
There is no word on what caused either crash.