According to authorities, the crash happened at about 10 a.m. near the bus garage at North Monroe Street and Martin Luther King Boulevard.
Two buses collided, injuring the driver of the DART bus and the driver and two passengers of a smaller bus from Saint Francis Hospital.
Both drivers were taken to the hospital where they were listed in stable condition.
Two passengers were also transported to the hospital, a 20-year-old male in stable condition, and a 90-year-old female in critical condition.
The crash is currently under investigation.