Officers responded to the intersection of 48th Street and Kingsessing Avenue at approximately 7:45 p.m.
At the scene, police found two people inside a car that crashed into a home and ended up on top of an SUV.
The driver died at the scene and the passenger was taken to a nearby hospital, where they are listed in stable condition.
There is no word yet on the driver's identity.
Investigators say the driver was traveling at a high rate of speed and lost control.
The house suffered minor damage, according to officials.