The crash happened around 6 a.m. Monday near the intersection of Stanton-Christiana Road and Old Route 7.
According to police, 23-year-old Jaiwon Pollard of Wilmington drove his Hyundai into the path of a woman's Mercedes.
Pollard was killed in the resulting crash. Police say he was not properly restrained at the time of the crash.
The woman driving the Mercedes was not seriously hurt.