It happened just before 10:30 a.m. at the intersection of South College Avenue and Welsh Tract Road.
Police said the 85-year-old driver of a Hyundai turned left in front of a pick-up truck and the two vehicles collided.
A female passenger in the Hyundai suffered very serious injuries and was flown to Christiana Hospital.
The driver was cited for failing to yield on a left turn.
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