The crash happened just before 1:30 a.m. Saturday at the intersection of Naaman's Road and Ebright Road when a car was struck head-on by another vehicle.
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Shortly after, a motorcyclist ran into the rear of the crash scene.
When crews arrived at the scene they found six people in need of medical attention.
A 22-year-old female, a 25-year-old female, and a 51-year-old female all suffered multiple injuries and were taken to the hospital in serious condition.
A 24-year-old male and a 22-year-old female also suffered injuries and were transported to the hospital in stable condition.
The driver of the motorcycle, a 25-year-old male, was also transported to the hospital in serious condition after suffering injuries to his arm, chest and knee.
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All patients were transported to Christiana Hospital.
Delaware State Police continue to investigate the crash.
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