It happened around 1:30 p.m. in Wilmington.
According to police, officers spotted the U-Haul on I-95 on Monday after it was reported stolen last week. Officers attempted to pull over the vehicle but a chase ensued.
The chase ended in a crash at 4th and Van Buren after the driver struck several cars, a light pole and a fence.
Two juvenile occupants of the U-Haul fled on foot but were later arrested.