It happened before 1:00 p.m. when the rear tire flew off a tractor-trailer on Route 13 on New Castle Road.
That wheel hit three cars that were stopped at a light in the northbound lanes.
Two people from one of the cars were taken to the hospital to be treated for neck and back pain.
The driver of the tractor-trailer says he only realized he lost the tire after noticing something wrong with his truck.
He pulled over immediately and contacted police.
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