The incident happened just before 7:30 p.m. on the 800 block of East Chelten Avenue.
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Police say a 32-year-old man was shot in the head and taken to Einstein Medical Center, where he was pronounced dead.
The second victim, a 25-year-old man, was also shot in the head.
He was transported to Einstein Medical Center and listed in extremely critical condition.
The third victim, a 33-year-old female, was shot once in the right foot.
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She was listed in stable condition at Einstein.
So far, no arrests have been made.
Anyone with information is asked to contact police.