Firefighters responded to the 1000 block of East Hortter Street just after 1:30 a.m. Sunday.
Upon arrival, crews found flames burning through two floors of a twin house, which then spread to the roof.
Investigators say a 9-year-old and another child were taken to an area hospital due to injuries sustained in the blaze. There was no immediate word on their conditions.
A woman was also treated at the scene by medics.
Officials say a total of 10 occupants were displaced by the fire. All of the residents are said to be from the same family.