It happened around 1:30 a.m. Friday at Hortter and Chew streets.
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Police said a gunman ambushed two people in a parked BMW sedan.
A 19-year-old woman in the passenger seat was not hit.
The 21-year-old driver was shot three times.
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Police said he managed to drive away but slammed into a parked car after a short distance.
That car rear-ended two other unoccupied vehicles.
The victim was taken to the hospital where he was pronounced dead.
No arrests have been made.